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ERMS source details

Chianese, G.; Silber, J.; Luciano, P.; Merten, C.; Erpenbeck, D.; Topaloğlu, B.; Kaiser, M.; Tasdemir, D. (2017). Antiprotozoal Linear Furanosesterterpenoids from the Marine Sponge Ircinia oros. Journal of Natural Products. 80(9): 2566-2571.
359946
10.1021/acs.jnatprod.7b00543 [view]
Chianese, G.; Silber, J.; Luciano, P.; Merten, C.; Erpenbeck, D.; Topaloğlu, B.; Kaiser, M.; Tasdemir, D.
2017
Antiprotozoal Linear Furanosesterterpenoids from the Marine Sponge <i>Ircinia oros</i>
Journal of Natural Products
80(9): 2566-2571
Publication
Available for editors  PDF available
Chemical investigation of the marine sponge Ircinia oros yielded four linear furanosesterterpenoids, including the known metabolites ircinin-1 (1) and ircinin-2 (2) and two new compounds, ircinialactam E (3) and ircinialactam F (4). Their chemical structures were elucidated by using a combination of [a]D, NMR, HRMS, and FT-IR spectroscopy. The absolute configuration of C-18 in compounds 1-3 was identified as R by electronic circular dichroism (ECD) spectroscopy coupled with time-dependent density functional theory calculations. Compounds 1-4 showed moderate leishmanicidal, trypanocidal, and antiplasmodial activities (IC50 values 28-130 µM). This is the second report of rare glycinyl lactam derivatives 3 and 4 from the genus Ircinia.
Mediterranean
Chemistry
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2019-11-30 17:05:28Z
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2019-12-01 09:13:13Z
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Ircinia oros (Schmidt, 1864) (additional source)
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