TY - JOUR AB - Chemical investigation of the marine sponge Ircinia oros yielded four linear furanosesterterpenoids, including the known metabolites ircinin-1 (1) and ircinin-2 (2) and two new compounds, ircinialactam E (3) and ircinialactam F (4). Their chemical structures were elucidated by using a combination of [a]D, NMR, HRMS, and FT-IR spectroscopy. The absolute configuration of C-18 in compounds 1-3 was identified as R by electronic circular dichroism (ECD) spectroscopy coupled with time-dependent density functional theory calculations. Compounds 1-4 showed moderate leishmanicidal, trypanocidal, and antiplasmodial activities (IC50 values 28-130 µM). This is the second report of rare glycinyl lactam derivatives 3 and 4 from the genus Ircinia. A1 - Chianese, G. A1 - Silber, J. A1 - Luciano, P. A1 - Merten, C. A1 - Erpenbeck, D. A1 - Topaloğlu, B. A1 - Kaiser, M. A1 - Tasdemir, D. DO - 10.1021/acs.jnatprod.7b00543 JO - Journal of Natural Products IS - 9 SP - 2566 EP - 2571 C1 - 80(9): 2566-2571 TI - Antiprotozoal Linear Furanosesterterpenoids from the Marine Sponge Ircinia oros UR - https://marbef.org/data../aphia.php?p=sourcedetails&id=359946 VL - 80 PY - 2017 Y2 - 2024-03-28 ER -