The subfamily Exogoninae was studied from samples collected in shallow waters of the fjords and channels of the Patagonian region of Chile. Two new species are described: Exogone yagan n. sp. and Erinaceusyllis carrascoi n. sp. The species Exogone heterosetoides , Erinaceusyllis bidentata and Erinaceusyllis perspicax are newly reported to Chile, as well as the genus Erinaceusyllis San Martín, 2005. Parapionosyllis brevicirra , Sphaerosyllis hirsuta and Salvatoria rhopalophora , n. comb., are also reported, with the latter redescribed. Finally, we redescribe Exogone anomalochaeta from Antarctica. Most of the species were found inside tubes of Chaetopterus cf. variopedatus ; this habitat is new for Exogoninae. This research is a new taxonomic account of Syllidae in Chile and improves the knowledge of Exogoninae of the Patagonian region. Corresponding author: E.H. Soto eulogio.soto@uv.cl
